KMID : 0352720230470040583
|
|
Journal of Ginseng Research 2023 Volume.47 No. 4 p.583 ~ p.592
|
|
Korean Red Ginseng extract attenuates alcohol-induced addictive responses and cognitive impairments by alleviating neuroinflammation
|
|
Kim Hee-Jin
Lee Min-Yeong Kim Gyu-Ri Lee Hyun-Jun Leandro Val Sayson Darlene Mae D. Ortiz Cheong Jae-Hoon Kim Mi-Kyung
|
|
Abstract
|
|
|
Background : Alcohol is one of the most commonly used psychoactive drugs. Due to its addictive characteristics, many people struggle with the side effects of alcohol. Korean Red Ginseng (KRG) is a traditional herbal medicine that is widely used to treat various health problems. However, the effects and mechanisms of KRG in alcohol-induced responses remain unclear. Therefore, the purpose of this study was to investigate the effects of KRG in alcohol-induced responses.
Methods : We investigated two aspects: alcohol-induced addictive responses and spatial working memory impairments. To determine the effects of KRG in alcohol-induced addictive responses, we performed conditioned place preference tests and withdrawal symptom observations. To assess the effects of KRG in alcohol-induced spatial working memory impairment, Y-maze, Barnes maze, and novel object recognition tests were performed using mice after repeated alcohol and KRG exposure. To investigate the potential mechanism of KRG activity, gas chromatography-mass spectrometry and western blot analysis were performed.
Results: KRG-treated mice showed dose-dependent restoration of impaired spatial working memory following repeated alcohol exposure. Furthermore, withdrawal symptoms to alcohol were reduced in mice treated with KRG and alcohol. The PKA-CREB signaling pathway was activated after alcohol administration, which was reduced by KRG. However, the levels of inflammatory cytokines were increased by alcohol and decreased by KRG.
Conclusion : Taken together, KRG may alleviate alcohol-induced spatial working memory impairments and addictive responses through anti-neuroinflammatory activity rather than through the PKA-CREB signaling pathway.
|
|
KEYWORD
|
|
Korean Red Ginseng, alcohol, spatial working memory, withdrawal symptoms, neuroinflammation
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|